Particle physics laboratory

Sun Lab wins first major NIH grant to study iron disorders – School of Medicine News


Shengyi Iris Sun, Ph.D., joined Wayne State University School of Medicine as an Assistant Professor of Molecular and Genetic Medicine, and Biochemistry, Microbiology and Immunology in July 2019, and has already received his first major grant from the National Institutes. of health.

Shengyi Iris Sun, Ph.D.

Dr Sun is the Principal Investigator on the “New Role of Endoplasmic Reticulum-Associated Degradation in Iron Metabolism,” supported by a five-year, $ 1.925 million grant from the National Institute of Diabetes and Digestive Diseases and kidney disease that started on December 1.

“Iron homeostasis disorders affect millions of people around the world, causing anemia, iron deficiency and increasing the risk of diabetes, liver disease and kidney disease if overloaded. We recently revealed a new role for endoplasmic reticulum-associated degradation, or ERAD, in the regulation of iron metabolism, ”said Dr. Sun.

ERAD is a primary endoplasmic reticulum, or ER, quality control machinery to remove misfolded ER proteins for proteasomal cytosolic degradation.

“However, its pathophysiological role in vivo remains largely uncertain,” said Dr Sun. “The objective of our study is to investigate the novel role of ERAD in the regulation of iron metabolism, in order to advance our understanding of the molecular mechanisms underlying diseases associated with iron disorders.

The project could significantly advance the understanding of iron-related disorders in humans and the pathogenesis of diseases associated with protein folding defects in general.

“I feel very excited and grateful to receive my first R01 award thanks to the hard work and support from my lab members and colleagues. We look forward to the exciting scientific journey to come with this support, ”added Dr Sun.

Dr. Sun’s collaborators include Yatrik Shah, Ph.D., professor of molecular and integrative physiology in the University of Michigan School of Medicine; Kezhong Zhang, Ph.D., professor of molecular medicine and genetics and biochemistry, microbiology and immunology at WSU; and Yu-ming Mindy Huang, Ph.D., assistant professor of physics and astronomy at the WSU.

The assignment number for this National Institutes of Health study is 1R01DK128077.

The project is also supported by the 2021-2022 University Research Grant from the WSU Office of the Provost and the Health Research Associates Grant Writing Aid Class provided by the WSU School of Medicine.